Vol. 2, Issue 1, Part A (2025)

Green synthesis of bimetallic nanoparticles has gained attention due to its environmental compatibility, cost effectiveness, and biological relevance. The present preliminary research explores a one pot green synthesis approach for silver zinc bimetallic nanoparticles using aqueous extract of Madagascar periwinkle (Sadāfuli), a medicinal plant traditionally valued for its bio energetic attributes. Phytochemicals present in the extract act simultaneously as reducing, stabilizing, and capping agents, enabling nanoparticle formation without hazardous reagents. The synthesized Ag-Zn nanoparticles were characterized preliminarily by visual observation, ultraviolet visible spectroscopy, and basic physicochemical assessment to confirm nanoparticle formation and stability. Biological screening focused on antimicrobial activity against selected bacterial strains and an exploratory evaluation of bio energetic responses based on observable biological interactions. The bimetallic system demonstrated enhanced antimicrobial potential compared to monometallic counterparts, suggesting a synergistic effect arising from the combined metallic composition. The interaction between plant derived metabolites and metal ions appears to play a critical role in modulating particle size, surface properties, and biological performance. Although the research is exploratory, the findings support the feasibility of using Sadāfuli extract for rapid and ecofriendly synthesis of biologically active Ag-Zn nanoparticles. The work provides initial insight into the convergence of green nanotechnology, traditional medicinal plants, and bio energetic considerations. These preliminary observations warrant detailed physicochemical characterization and advanced biological validation in future studies. Overall, the research highlights the potential of one pot green synthesis routes as sustainable platforms for developing multifunctional bimetallic nanomaterials with promising antimicrobial and bio interactive properties. Such integrative approaches may bridge traditional knowledge with modern nanoscience, offering scalable solutions for low cost biomedical applications, particularly in resource limited settings where sustainable synthesis and multifunctional activity are simultaneously required, and this conceptual framework encourages further interdisciplinary research across materials science, microbiology, and traditional medicine systems to validate efficacy, safety, and reproducibility globally applicable.